Central Nervous System Histoplasmosis in Acquired Immunodeficiency Syndrome

Paradoxical central nervous system immune reconstitution syndrome in acquired immunodeficiency syndrome-related primary central nervous system lymphoma.

Acquired immunodeficiency syndrome

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Cutaneous histoplasmosis in acquired immunodeficiency.

On examination, the patient was toxic with a pulse rate of 124/min, BP 120/76 mm of Hg, respiration rate of 34/min and had generalized, discrete, non-tender lymphadenopathy. The respiratory, cardiovascular and gastrointestinal system were essentially within normal limits. Chest X-ray revealed diffuse miliary mottling (Fig. 1). He was put on antituberculosis drugs. Three days after admission, he...

Histoplasmosis of the central nervous system.

Histoplasma capsulatum infection of the central nervous system is extremely rare in the United Kingdom partly because the organism is not endemic. However, because the organism can remain quiescent in the lungs or the adrenal glands for over 40 years before dissemination, it increasingly needs to be considered in unexplained neurological disease particularly in people who lived in endemic areas...

Histoplasmosis of the Central Nervous System

Histoplasmosis of the central nervous system (CNS) is not an uncommon complication of Histoplasma capsulatum infection since it occurs in ∼2% to 20% of disseminated cases. CNS histoplasmosis carries a mortality rate that ranges from 11.1% to 100%, and the risk factors for dissemination to the brain have yet to be determined. Diagnosis is often difficult and time consuming, which can result in d...